★★★    15th The Society for  Hard Tissue Regenerative Biology Conference     ★★★

September, 16. 2006 Kyoto University  ( Kyodai kaikan. Hall )

8:50−9:00

Chairman Yasuhiko Tabata

ASS Organizer Noriyuki Nagai

9:00−10:00   Asian Science Seminar

Background & Chairman:

Noriyuki Nagai (Okayama University), Jing Xiao (JSPS fellow, China)

ASS-1 Preferential Expression of Heparanase Protein Correlates with Early Invasion and Progression of oral Mucosal Melanoma

Rosario Santos Rivera1, 2, Hitoshi Nagatsuka2, Ryo Tamamura2, Jing Xiao2, 3, Noriyuki Nagai2

1University of the East, Manila, Philippines, 2Okayama University, Okayama, Japan

3Dalian Medical University, China

ASS-2 Sequential expression of Notch1, HES5, Jagged2, and Math1 in molar tooth germ of mouse

Silvia Susana Borkosky1, 2, Naoki Katase2, Phuu Pwint Han2, 3, Mehmet Gunduz2,

Hitoshi Nagatsuka2

1Tucuman National University, Tucuman, Argentina,

2Okayama University, Okayama, Japan, 3Institute of Dental Medicine, Yangon, Myanmar

ASS-3 Mutation Analysis of the EGFR Pathway in Head and Neck Squamous Cell Cancer

Mahmoud AL Sheikh Ali1, 2, Mehmet Gunduz2, Hitoshi Nagatsuka2, Beyhan Cengiz2, 3,

Esra Gunduz2, Ryo Tamamura2, Noriyuki Nagai2

1Jordan University, Jordan, 2Okayama University, Okayama, Japan,

3Gaziantep Medical School, Turkey

ASS-4 Biological analysis of bone marrow stromal cells in vivo cell culture method

Mathieu Bernard Lefevre1, 2, Andrea Paola Rodriguez2, 3, Hidetsugu Tsujigiwa2, Hitoshi Nagatsuka2,

Noriyuki Nagai2

1Paris V University, France, 2Okayama University, Okayama, Japan

3Tucuman National University, Tucuman, Argentina

ASS-5 Mechanism of new bone formation by using immature stem cell KUSA/A1 for bone tissueengineering in vivo

Sathi Gulsan Ara1, 2, Andrea Paola Rodriguez2, 3, Hidetsugu Tsujigiwa2, Hitoshi Nagatsuka2,

Noriyuki Nagai2

1Bangladesh Dental College, Dhaka, Bangladesh, 2Okayama University, Okayama, Japan ,

3Tucuman National University, Tucuman, Argentina

ASS-6 Development of CaTiO3-C coating material for Dental Implant

Mika Okauchi1, Ryo Tamamura1, Ko Kai Ryuu1, 2, Kan Rui1, 2, Jing Xiao1, 3,Keisuke Nakano1,

Noriyuki Nagaoka1, Katsunori Kanata1, Toru Takagi1, Masaru Akao1, Noriyuki Nagai1

1Okayama University, Japan, 2China Medical University, China

3Dalian Medical University, China

10:00−10:10   Coffee Break

10:10−11:20　 Symposium

Chairman  Takashi Takada（Hiroshima Univ.）

S-1 Functional Scaffold for Tissue Engineering

Yoshiaki Hirano

Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology.

S-2 Hepatocyte Growth Factor in Tissue Regeneration and Anti-fibrosis

Kunio Matsumoto

Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine

S-3 Regeneration induction therapy based on DDS technology of growth factors

Masaya Yamamoto and Yasuhiko Tabata

Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University

S-4 Evaluation Technique for Regenerative Bone Tissue

Takayoshi Nakano

Course of Materials Science & Engineering, Division of Materials & Manufacturing Science,

Graduate School of Engineering, Osaka University

11:20−12:20   Special Lecture�T

Chairman Tohru Nakanishi （Syujitsu Univ.）

SP-1 The rapeutic utilization of human embryonic stem cells

Hirofumi Suemori

Laboratory of Embryonic Stem Cell Research, Stem Cell Research Center, Institute for Frontier Medical Sciences,

Kyoto University, Japan

12:20−13:10    Break

13:10−13:30

13:30−14:30   Special Lecture�U

Chairman Seishi Nakanishi （Osaka Medicccal Univ.）

SP-2 Regenerative medicine in oral and maxillofacial surgery using bone morphogenetic proteins

Kazuhisa Bessho

Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan

14:30−14:50   Memorial Aword  of The Society for Regenerative Hard Tissue Biology

Chairman Toshiyuki Kawakami （Matsumoto Dental Univ.）

2006 Aword

Yousuke Gotoh、Takashi Matsuura, Hironobu Sato

Fukuoka Dental Univ.

Special Lecture of 2005 Aword

SP-3   Gene Expression of Matrix Proteins in Cbfa1-Knockout Mice

Hitoshi NAGATSUKA

Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,

Okayama University, Japan

14:50−15:10 Coffee Break

15:10−15:50 Lecture�T

Chairman  Hidemitsu Harada （Iwate Medical Univ.）

OA-1  Induction of bone and cartilage by functionally graded-HAp / BMP-2 on rat skull periosteum

Jun Hino1, Masaru Murata1, Toshiyuki Akazawa2, Mie Naraoka2, Junichi Tazaki1, and Makoto Arisue1

1. Second Department of Oral and Maxillofacial Surgery, School of DentistryHealth Sciences University of Hokkaido

2. Department of Materials Technology, Hokkaido Industrial Research Institute

OA-2 Properties of osteoinduction and BMP-2 release in functionally graded Hap

Junichi Tazaki1, Masaya Yamamoto2, Yasuhiko Tabata2, Toshiyuki Akazawa3, Jun Hino1, Masaru Murata1,

and Makoto Arisue1

1. Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido

2. Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University

3. Department of Materials Technology, Hokkaido Industrial Research Institute

OA-3 Geometry of artificial extracellular matrices: BMP-induced ectopic osteogenesis with three geometrically different titanium-webs

Youichi Uramoto1, Hiroko Takita2, Yoshinori Kuboki3 and Masato Tamura1

1. Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University

2. Central Research Institute, 3. Koken Bioscience Institute

OA-4 Rationale for hydroxyapatite coating on 3D-titanium web enhancing bone formation

Yoshinori Kuboki 1, 2, John A. Jansen3, Johan W. M. Vehof 3, Ryota Yoshimoto4, Tohru Kaku5, Hiroyuki Shiota6, Yasuo Seki6 and

Hiroko Takita7

1. Professor Emeritus, Hokkaido University, 2. Koken Bioscience Institute

3. School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands University

4. Second Department of Oral Maxillofacial Surgery and

5. Department of Oral Pathology, Hokkaido Health Sciences University of Hokkaido,

6. Medical Device Department, Hi-Lex Corporation

7. Central Research Institute, Graduate School of Dental Medicine, Hokkaido University,

15:50−16:30

Chairman Yoshinori Kuboki Hokkaido Univ.）

OA-5 RANKL induces the expression of carbonic anhydrase II, cathepsin K, and matrix metalloproteinase-9 in RAW264.7 cells

Kyosuke Fujisaki1, Natsuko Tanabe2,3, Naoto Suzuki3,4, and Masao Maeno2,

1. Department of Endodontics, Nihon University School of Dentistry

2. Department of Oral Health Sciences, Nihon University School of Dentistry

3. Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry

4.  Department of Biochemistry, Nihon University School of Dentistry

OA-6 Runx2 expression in mandibular condylar cartilage development

Takako Shimizu1, Hitoshi Nagatsuka2, Hidetsugu Tsujigiwa2, Takehiro Watanabe1, Norimasa Okafuji1, Saburo Kurihara1,

Noriyuki Nagai2, and Toshiyuki Kawakami1

1. Matsumoto Dental University  2. Okayama University

OA-7 Effects of phosphate on mineralization related gene expression of dental follicle cell

Sunao Sato1, Masae Kitagawa2, Shinji Iizuka1, Kiyako Sakamoto1, Hiroko Oka1, Mutsumi Miyauchi1, Brian Foster3,

Martha Somerman3, and Takashi Takata1

1. Department of Oral Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University

2. Center of Oral Clinical Examination, Hiroshima University Hospital

3. Department of Periodontics, School of Dentistry, University of Washington

OA-8 Forming mechanism of extracellular matrix containing periodontal ligament-like collagen fiber and its bone inducing activity

Kikuji Yamashita１, Akemichi Ueno2, Jun Ishibashi１, Naohiro Ohshita１, and Seiichiro Kitamura１

1. Department of Oral and Maxillofacial Anatomy, Institute of Health Bioscience,University of Tokushima Graduate School

2. Department of Hygiene Chemistry, School of Pharmaceutical Sciences, Ohu University

16:30−17:00 Lecture�V

Chairman Masaru Murata（ Health Sciences University of Hokkaido）

OA-9 Mechanisms of HERS formation and development of tooth root formation technology

Hidemitsu Harada1, Tadayoshi Kagiya1, Naoki Fujiwara1, Yasuhiko Tabata2, and Kiyoto Ishizeki1

1. Department of Oral Anatomy II, Iwate Medical University, School of Dentistry

2. Department of Biomaterials, Institute for Frontier Medical Science, Kyoto University

OA-10 Application of micro-CT to observe the tissue surrounding dental implants at rabbit’s bone

Yasuko Numata１, Toshiro Sakae２, Hiroshi Nakada３, Taketoshi Suwa１, Takao Kato4, Takahiro Yazaki３,  Katsuhisa

Kuwahara３, and Kihei Kobayashi３

1. Gnatho-Oral Prosthetic Rehabilitation, Nihon University School of Dentistry at Matsudo

2. Department of Histology and Cytology, Nihon University School of Dentistry at Matsudo

3. Department of Gnatho-Oral Prosthetic Rehabilitation, Nihon University School of Dentistry at Matsudo

4. Department of Oral and Maxillofacial Implantology, Nihon University School of Dentistry at Matsudo

OA-11 Phase Contrast Imaging of Dental Tissues

Toshiro Sakae1, Taketoshi Suwa1, Yasuko Numata1, Hiroshi Nakada1, Yukie Sato1, Hiroyuki Okada1,

Hirotsugu Yamamoto1, Hirotsugu Yamamoto1, Tohru Hayakawa1, Kaoru Suzuki2, Takao Kuwada3, Yasushi Hayakawa3,

Toshinari Tanaka3, Ken Hayakawa3, and Isamu Sato3

1. School of Dentistry, Nihon University at Matsudo,  2. Faculty of Science and Technology, Nihon University

3. LEBRA, Nihon University

17:00−17:10 Close