Rationale for hydroxyapatite coating on 3D-titanium web enhancing bone formation


Yoshinori Kuboki 1, 2, John A. Jansen3, Johan W. M. Vehof 3, Ryota Yoshimoto4,

Tohru Kaku5, Hiroyuki Shiota6, Yasuo Seki6 and Hiroko Takita7


1Professor Emeritus, Hokkaido University, 2Koken Bioscience Institute

3School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands University

4Second Department of Oral Maxillofacial Surgery and

5Department of Oral Pathology, Hokkaido Health Sciences University of Hokkaido,

6Medical Device Department, Hi-Lex Corporation

7Central Research Institute, Graduate School of Dental Medicine, Hokkaido University,


Hydroxyapatite coating on titanium implants is generally believed to increases isotopic bone formation, but there is no direct quantitative evidence. In this paper, we demonstrated that, for the first time, a new method of sputtering of calcium phosphate (2 micron thickness) on a new device of 3-dimensional titanium web (TW, composed of titanium fibers with 50 micron diameter) clearly induced 4 - 5 times higher amount of bone formation in the Ca-P coated Ti mesh than the non-coated one, judging from Ca contents and alkaline phosphatase activity at 6 weeks. A new insight on the mechanism of enhancement bone formation is to be presented.