OA-4

Rationale for hydroxyapatite coating on 3D-titanium web enhancing bone formation

Yoshinori Kuboki ^{1, 2}, John A. Jansen³, Johan W. M. Vehof ³, Ryota Yoshimoto⁴,

Tohru Kaku⁵, Hiroyuki Shiota⁶, Yasuo Seki⁶ and Hiroko Takita⁷

¹Professor Emeritus, Hokkaido University, ²Koken Bioscience Institute

³School of Dentistry, University of Nijmegen, Nijmegen, The Netherlands University

⁴Second Department of Oral Maxillofacial Surgery and

⁵Department of Oral Pathology, Hokkaido Health Sciences University of Hokkaido,

⁶Medical Device Department, Hi-Lex Corporation

⁷Central Research Institute, Graduate School of Dental Medicine, Hokkaido University,

Hydroxyapatite coating on titanium implants is generally believed to increases isotopic bone formation, but there is no direct quantitative evidence. In this paper, we demonstrated that, for the first time, a new method of sputtering of calcium phosphate (2 micron thickness) on a new device of 3-dimensional titanium web (TW, composed of titanium fibers with 50 micron diameter) clearly induced 4 - 5 times higher amount of bone formation in the Ca-P coated Ti mesh than the non-coated one, judging from Ca contents and alkaline phosphatase activity at 6 weeks. A new insight on the mechanism of enhancement bone formation is to be presented.