OA-2

Properties of osteoinduction and BMP-2 release in functionally graded HAp

Junichi Tazaki¹, Masaya Yamamoto², Yasuhiko Tabata², Toshiyuki Akazawa³,

Jun Hino¹, Masaru Murata¹, and Makoto Arisue¹

¹Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido

²Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University

³Department of Materials Technology, Hokkaido Industrial Research Institute

The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks(3×3×3mm), based on different surface structures. Spongy and cortical bones in bovine femur were calcined at 800℃ by the step-wise calcinations to obtain bulk HAp (b-HAp). The functionally graded HAp (fg-HAp) was designed by the partial dissolution-precipitation method. We estimated the in vivo release profile of ¹²⁵I–labeled BMP-2 and induction of hard tissues histologically. Specific nano-micro structures and biodegradation of fg-HAp is more effective for both BMP-2 retention and bone induction, compared to b-HAp, in the ectopic model.